Core 2

Tools to Assemble Virtual Whole Cells for Multi-scale, Multi-modal Simulations

Core 2 is developing detailed structural models, based on challenges defined by Driving Biomedical Projects (DBPs), centering on the molecular underpinnings of cellular processes. Where appropriate, we are extending these visible cell assembly tools to facilitate studies in which simulations are being developed to examine how cellular and subcellular activities contribute to organ or organism physiology, such as in heart disease, cancer, and aging.

Thus, the focus of this core is to develop technologies that advance:

  1. handling and refining experimental data from structural biology and microscopy to link critical length scales from subnanometer to 10s of microns – up to the dimensions of whole-tissue cells,
  2. making it routine for investigators to import data from multiple resources to assemble biological structural models at subcellular scales with increased realism and known accuracy,
  3. (3) connecting these realistic in silico representations of complex biological systems to DBPs that use multiple software tools to simulate the activation of biological processes.

A key outcome is to enable investigators to explore interactions among multiple microphysiological events using spatial frameworks as scaffolds to traverse the relevant subcellular domains and cover the range of temporal scales associated with the biological process being explored.