Patient-specific atrial model - courtesy of M Gonzales & S Narayan. Over the last two decades, breakthroughs in the research methodologies employed by experimental physiologists and clinical scientists have paved the way for an explosion in the quality and quantity of available data. These developments have underpinned many of the post-genomic era's advances in understanding, enabling the analysis of specific physiological systems through the collection of unique individual data sets. In parallel with these experimental developments, advances in computational and numerical techniques have accelerated our capacity to derive new knowledge; making possible the integration of multiple data sets through the application of bio-physically based computational models. These modelling developments now provide the potential for analysing complex cause and effect relationships and facilitating the development of improved mechanistic understanding in a range of physiological systems. Through the efforts of an active and multi-disciplinary research community the heart has emerged as arguably the most advanced current exemplar of this approach. Building on the momentum generated from the previous Cardiac Physiome Workshops held in:
the 2012 Cardiac Physiome will be held in San Diego from Oct 31st - Nov 2nd, at the Catamaran Resort on Mission Bay. The focus of the meeting continued our theme of combining both experimental and modelling research focused on understanding cardiac physiology across scales of biological organization from molecule to organ system.